ADMINISTRATION
Administration
- Intravenous infusion, preferably via central venous line
Infusion rate:
- Administer for 20-30 minutes
- Do not exceed 1 g/kg/hour to avoid circulatory overload.
Frequency:
- Repeat every 4-6 hours according to clinical need
- Not to exceed 24 hours of continuous use without re-evaluation.
GENERAL CONSIDERATIONS
Monitoring:
- Intracranial pressure
- Neurological status
- Blood pressure and heart rate
- Water balance and diuresis
- Serum electrolytes, especially sodium
- Serum osmolarity (maintain <320 mOsm/L)
- Renal function
Caution
Consider the “rebound effect” with prolonged use
Avoid in patients with severe renal insufficiency.
Use with caution in patients with heart failure.
Monitor for possible dehydration and electrolyte imbalance.
EN 
ES